Multivariable Cox regression analysis of association between ΔcholineC3 and progression-free survival, adjusting for cohort, PD-L1, TMB and ΔctDNAC3
| Covariate | HR (95% CI) | P value | Global p value |
| ΔcholineC3 | 0.001 | ||
| Decrease from baseline | Reference | ||
| Increase from baseline | 0.35 (0.20 to 0.64) | ||
| Cohort | 0.001 | ||
| A | Reference | ||
| B | 4.64 (1.74 to 12.37) | 0.0022 | |
| C | 2.99 (1.13 to 7.86) | 0.027 | |
| D | 0.74 (0.22 to 2.47) | 0.63 | |
| E | 0.9 (0.41 to 1.95) | 0.78 | |
| PD-L1 (per percentage point) | 0.99 (0.98 to 1) | 0.17 | |
| log TMB | 0.81 (0.59 to 1.12) | 0.21 | |
| ΔctDNAC3 | 0.001 | ||
| Increase from baseline | Reference | ||
| Decrease from baseline | 0.33 (0.18 to 0.59) |
ctDNA, Circulating tumor DNA; PD-L1, Program Death-Ligand 1; TMB, tumor mutation burden.