Selected hyperprogression disease definitions
| Tumor growth parameter | Definition of tumor growth acceleration | Prebaseline tumor assessment | Tumor evaluation | TTF | References |
| TGR | TGV=3log(Vt/V0)/dt TGR=TGVPOST/TGVPRE≥2 | Yes | Target lesions | N/A | Champiat et al13 |
| TGK | TGD=St−S0/dt TGK=TGDPOST/TGDPRE≥2 | Yes | Target lesions | N/A | Saâda-Bouzid et al26 |
| Early tumor burden increase | >40% increase in target lesion sum from baseline ≥2 new lesions in an organ already involved at the first spread to a new organ at the first radiological evaluation | No | Target lesions and new lesions | ≤2 months | Matos et al20 |
| Combined parameters | TGK* or TGR†+TTF <2 months | Yes | Target lesions and new lesions | ≤2 months | Saâda-Bouzid et al26, Kim et al27 |
Tumor volume V=4πR3/3.
dt, difference between two points of time; N/A, not applicable; S, sum of major diameter of target lesions; TGD, tumor growth diameter; TGK, tumor growth kinetic represents the change of tumor diameters in a two-dimensional approach; TGR, tumor growth rate represents the change of tumor volume in a three-dimensional approach; TGV, tumor growth volume; TTF, time to failure when progression was detected.