Table 1

Summary of clinical and preclinical studies assessing the prevention of Lynch syndrome

Phase	Study type	Agent	Disease	Delivery platform	Animal model	Clinical trial no	Clinical trial title	Status	Publication
I and II	Immuno-prevention	FSPs: 209 Neoantigens	Lynch Syndrome	Adenovirus and Modified vaccinia Ankara virus	n/a	NCT05078866	Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients	Not yet recruiting	n/a
I and II	Immuno-prevention	FSPs: CASP-5 and TGFBR2; TAA: CEA	Lynch Syndrome	Dendritic Cell	n/a	NCT01885702	Dendritic Cell Vaccination in Patients with Lynch Syndrome or Colorectal Cancer With MSI	Active, not recruiting	121
I and II	Immuno-prevention	FSPs: AIM2, HT001 and TAF1B	Lynch Syndrome	Peptide vaccination	n/a	NCT01461148	Vaccination Against MSI Colorectal Cancer	Completed	115
Preclinical	Immuno-prevention	Cancer neoantigens	Melanoma, Lymphoma, other	RNA	dogs	n/a	Vaccination Against Canine Cancer	Recruiting	114
Preclinical	Immuno-prevention and chemoprevention	Aspirin, Naproxen; FSPs: Nacad, Xirp1, Maz, Senp6	Lynch Syndrome	Peptide vaccination	Lynch syndrome mouse model	n/a	Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity with Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model	Completed	120
Preclinical	Immuno-prevention	FSPs: Senp6	Lynch Syndrome	Dendritic Cell	tumor transplantation mouse model	n/a	On the development of a neoantigen vaccine for the prevention of Lynch Syndrome	Completed	130

Search terms: prevention and Lynch syndrome or frameshift peptides.
45 Finn OJ. The dawn of vaccines for cancer prevention. Nat RevImmunol 2018;18:183–94.