Adverse events that were related to NY-ESO-1 TCR-gene transduced T cell infusion (n=9)
Grade 1–2 | Grade 3 | |
Any treatment-related adverse events | 7 (77%) | 1 (11%) |
Interstitial lung disease | 0 | 1 (11%) |
Cytokine release syndrome | 3 (33%) | 0 |
Fever | 3 (33%) | 0 |
Diarrhea | 2 (22%) | 0 |
Malaise | 2 (22%) | 0 |
Hypoalbuminemia | 2 (22%) | 0 |
Anorexia | 1 (11%) | 0 |
Constipation | 1 (11%) | 0 |
Hot flush | 1 (11%) | 0 |
Edema limbs | 1 (11%) | 0 |
Purpura | 1 (11%) | 0 |
Tumor pain | 1 (11%) | 0 |
Tachycardia | 1 (11%) | 0 |
Platelet count decreased | 1 (11%) | 0 |
Alanine aminotransferase increased | 1 (11%) | 0 |
Ferritin increased | 1 (11%) | 0 |
Fibrinogen decreased | 1 (11%) | 0 |
Hyperkalemia | 1 (11%) | 0 |
Hyperuricemia | 1 (11%) | 0 |
Proteinuria | 1 (11%) | 0 |
Plasma creatinine increase | 1 (11%) | 0 |
TCR, T cell receptor.