Table 3

Best overall response per RECIST V.1.1 across MMRD tumor sites

Brain (n=8)Colon (n=33)Endometrium (n=29)Gastric (n=8)Small intestine (n=5)Others (n=17)All (n=100)
ORR no. (%; 95% CI)0 (0.0; 0.0 to 0.0)14 (42; 24.6 to 60.2)13 (45; 25.6 to 60.2)3 (38; 0.0 to 80.7)5 (100; 100 to 100)7 (41; 15.1 to 67.3)42 (42; 32.2 to 51.8)
CR no. (%)0 (0.0)6 (18.2)4 (13.8)2 (25.0)1 (20.0)2 (11.7)15 (15.0)
PR no. (%)0 (0.0)8 (24.2)9 (31.0)1 (12.5)4 (80.0)5 (29.4)27 (27.0)
SD no. (%)1 (12.5)13 (39.4)8 (27.6)2 (25)0 (0.0)4 (23.5)28 (28.0)
PD no. (%)7 (87.5)6 (18.2)8 (27.6)3 (37.5)0 (0.0)6 (35.2)30 (30.0)
  • CR, complete response ; MMRD, mismatch repair-deficient ; ORR, objective response rate ; PD, progressive disease; PR, partial respose; RECIST, Response Evaluation Criteria in Solid Tumors ; SD, stable disease.