Table 1

Collection of protein kinase inhibitors used for CD39 screening

#	Drug	Trade name	CAS-number	Target
1	Abemaciclib	Verzenio	1231929-97-7	CDK4/6
2	Acalabrutinib	Calquence	1420477-60-6	Bruton tyrosine kinase
3	Afatinib	Tovok	850140-72-6	EGFR, ErbB2, ErbB4
4	Alectinib	Alecensa	1256580-46-7	ALK and RET
5	Axitinib	Inlyta	319460-85-0	VEGFR1/2/3, PDGFRβ
6	Baricitinib	Olumiant	1187594-09-7	JAK1/2
7	Binimetinib	Mektovi	606143-89-9	MEK1/2
8	Bosutinib	BOSULIF	380843-75-4	BCR-Abl, Src, Lyn, and Hck
9	Brigatinib	Alunbrig	1197953-54-0	ALK, ROS1, IGF-1R, Flt3, EGFR
10	Cabozantinib	Cometriq	849217-68-1	RET, MET, VEGFR1/2/3, Kit, TrkB, Flt3, Axl, Tie2
11	Ceritinib	Zykadia	1032900-25-6	ALK, IGF-1R, InsR, ROS1
12	Cobimetinib	Cotellic	934660-93-2	MEK1/2
13	Crizotinib	Xalkori	877399-52-5	ALK, MET (HGFR), ROS1, MST1R
14	Dabrafenib	Tafinlar	1195765-45-7	B-Raf
15	Dacomitinib	Visimpro	1110813-31-4	EGFR family
16	Dasatinib	Sprycel	302962-49-8	BCR-Abl, EGFR, Src, Lck, Yes, Fyn, Kit, EphA2, PDGFRβ
17	Encorafenib	Braftovi	1269440-17-6	B-Raf
18	Erdafitinib	Balversa	1346242-81-6	FGFR1/2/3/4
19	Erlotinib	Tarceva	183319-69-9	EGFR
20	Everolimus	Afinitor	159351-69-6	FKBP12/mTOR
21	Fostamatinib	Tavalisse	901119-35-5	Syk, Spleen tyrosine kinase
22	Gefitinib	Iressa	184475-35-2	EGFR
23	Gilteritinib	Xospata	1254053-43-4	Flt3
24	Ibrutinib	Imbruvica	936563-96-1	Bruton tyrosine kinase
25	Idelalisib	Zydelig	870281-82-6	Phosphatidylinositol-3- Kinase
26	Imatinib	Gleevec	152459-95-5	BCR-Abl, Kit, and PDGFR
27	Lapatinib	Tykerb	231277-92-2	EGFR, ErbB2
28	Larotrectinib	Vitrakvi	1223403-58-4	TRK
29	Lenvatinib	Lenvima	417716-92-8	VEGFR1/2/3, PDGFR, FGFR, Kit, RET
30	Lorlatinib	Lorbrena	1454846-35-5	ALK
31	Midostaurin	Rydapt	120685-11-2	Flt3, PDGFR, VEGFR2, PKC
32	Neratinib	Nerlynx	698387-09-6	ErbB2/HER2
33	Nilotinib	Tasigna	641571-10-0	BCR-Abl, PDGFR, DDR1
34	Nintedanib	Vargatef	656247-17-5	FGFR1/2/3, PDGFRα/β, VEGFR1/2/3, Flt3
35	Osimertinib	Tagrisso	1421373-65-0	EGFR T970M
36	Palbociclib	Ibrance	571190-30-2	CDK4/6
37	Pazopanib	Votrient	444731-52-6	VEGFR1/2/3, PDGFRα/β, FGFR1/3, Kit, Lck, Fms, Itk
38	Ponatinib	Iclusig	943319-70-8	BCR-Abl, BCR-Abl T315I, VEGFR, PDGFR, FGFR, EphR, Src family kinases, Kit, RET, Tie2, Flt3
39	Regorafenib	Stivarga	755037-03-7	VEGFR1/2/3, BCR-Abl, B-Raf, B-Raf (V600E), Kit, PDGFRα/β, RET, FGFR1/2, Tie2, and Eph2A
40	Ribociclib	Kisqali	1211441-98-3	CDK4/6
41	Ruxolitinib	Jakafi	941678-49-5	JAK1/2
42	Sirolimus	Rapamycin	53123-88-9	FKBP/mTOR
43	Sorafenib	Nexavar	284461-73-0	VEGFR1/2/3, B-/C-Raf, mutant B-Raf, Kit, Flt3, RET, and PDGFRß
44	Sunitinib	Sutent	557795-19-4	PDGFRα/β, VEGFR1/2/3, Kit, Flt3, CSF-1R, Axl, and RET
45	Temsirolimus	Torisel	162635-04-3	FKBP12/mTOR
46	Tivozanib	Fotivda	475108-18-0	Multikinase inhibitor, eg, VEGF receptor tyrosine kinase
47	Tofacitinib	Tasocitinib	477600-75-2	JAK3
48	Trametinib	Mekinist	871700-17-3	MEK1/2
49	Vandetanib	Zactima	443913-73-3	RET, EGFRs, VEGFRs, Brk, Tie2, EphRs, and Src family kinases
50	Vemurafenib	Zelboraf	918504-65-1	A/B/C-Raf and B-Raf (V600E)