Variable | Any grade | Grade 2 | Grade 3 | Grade 4 |
Adverse events | ||||
Fatigue | 9 | 6 | 3 | – |
Abdominal pain | 2 | 1 | – | – |
Diarrhea | 11 | 1 | – | – |
Nausea | 7 | 1 | – | – |
Rash | 25 | 9 | 5 | – |
Anorexia | 11 | 2 | – | – |
Pruritus | 3 | 1 | – | – |
Cough | 5 | 1 | – | – |
Abnormal laboratory values | ||||
Alanine aminotransferase | 7 | 5 | 2 | – |
Bilirubin | 2 | 1 | – | – |
Aspartrate aminotransferase | 9 | 4 | 3 | – |
Alkaline phosphatase | 11 | 4 | 3 | – |
Anemia | 12 | 5 | 1 | – |
Neutropenia | 1 | 1 | – | – |
Thrombocytopenia | 8 | 4 | 1 | – |
Lipase | 6 | 4 | 3 | |
Amylase | 5 | 1 | 1 | – |
Hypothyroidism | 3 | 1 | – | – |
Hyponatremia | 4 | – | 2 | – |