Table 2

Most common adverse events

VariableAny gradeGrade 2Grade 3Grade 4
Adverse events
 Fatigue963
 Abdominal pain21
 Diarrhea111
 Nausea71
 Rash2595
 Anorexia112
 Pruritus31
 Cough51
Abnormal laboratory values
 Alanine aminotransferase752
 Bilirubin21
 Aspartrate aminotransferase943
 Alkaline phosphatase1143
 Anemia1251
 Neutropenia11
 Thrombocytopenia841
 Lipase643
 Amylase511
 Hypothyroidism31
 Hyponatremia42