Table 2

Clinical outcomes by receipt of bridging therapy

OutcomeBridging therapy (N=92)No bridging therapy (N=143)P value
ORR79.4%88.8%0.047
CR rate63.0%65.7%0.674
Median OS (months)22.9Not reached0.005
Median PFS (months)6.03Not reached0.039
CRS (all grades)76.1%79.0%0.597
CRS (grade 3+)4.4%7.0%0.574
ICANS (all grades)54.4%52.5%0.776
ICANS (grade 3+)20.7%23.1%0.748
  • CR, complete response; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity syndrome; ORR, overall response rate; OS, overall survival; PFS, progression-free survival.