Table 5

Response to C-CAR088 T cell therapy in ITT population

Best overall response, n (%)Low-dose groupMedium-dose groupHigh-dose groupTotal
ITT populationn=4n=13n=14n=31
ORR3 (75.0)11 (84.6)13 (92.9)27 (87.1)
 sCR0 (0.0)5 (38.5)8 (57.1)13 (41.9)
 CR0 (0.0)1 (7.7)2 (14.3)3 (9.7)
 VGPR3 (75.0)4 (30.8)2 (14.3)9 (29.0)
 PR0 (0.0)1 (7.7)1 (7.1)2 (6.5)
SD0 (0.0)0 (0.0)1 (7.1)1 (3.2)
Not evaluable1 (25.0)2* (15.4)0 (0.0)3 (9.7)
  • *One patient withdrew on week 2 and the other one died on day 3.

  • CR, complete response; ITT, intention-to-treat; ORR, overall response rate; PR, partial response; sCR, stringent CR; SD, stable disease; VGPR, very good partial response.