Table 2

Summary of AEs

Patients with adverse events, no (%)*
Any gradeGrade 3–4
All causality AEs41 (98)8 (19)
Treatment-related AEs33 (79)8 (19)
Related to SIRT21 (50)2 (5)
Related to nivolumab (IMAE)27 (64)6 (14)
All causality SAEs21 (50)11 (26)
Treatment-related SAEs5 (12)5 (12)
Related to SIRT1 (2)1 (2)
Related to Nivolumab (IMAE)4 (9)4 (9)
AEs of special interest with incidence >10%
Hepatic30 (71)8 (19)
Blood16 (38)0
Gastrointestinal16 (38)3 (7)
Skin12 (29)0
Endocrine10 (24)2 (5)
  • *AEs and SAEs are reported separately.

  • AE, adverse event; SAEs, serious AEs; SIRT, selective internal radiation therapy.