Focality of papillary thyroid cancer in NOD.H2h4 TPO-CRE-ER BRAFv600E mice treated with immune checkpoint inhibitors (ICIs), according to the status of iodine-exacerbated thyroiditis (IET)
| No of mice | Papillary thyroid cancer foci | P value | |||
| None | One | ≥2 | |||
| Concomitant IET: | 0.107 | ||||
| Control | 18 | 0 | 5 | 13 | |
| LAG-3 Ab | 8 | 3 | 2 | 3 | |
| PD-1 Ab | 8 | 4 | 1 | 3 | |
| TIM-3 Ab | 6 | 2 | 1 | 3 | |
| No IET: | 0.974 | ||||
| Control | 19 | 3 | 4 | 12 | |
| LAG-3 Ab | 6 | 1 | 1 | 4 | |
| PD-1 Ab | 7 | 2 | 1 | 4 | |
| TIM-3 Ab | 6 | 2 | 1 | 3 | |
| Pre-existing IET: | 0.242 | ||||
| Control | 21 | 10 | 9 | 2 | |
| LAG-3 Ab | 9 | 4 | 3 | 2 | |
| PD-1 Ab | 7 | 2 | 1 | 4 | |
| TIM-3 Ab | 7 | 2 | 2 | 3 | |
| | No of mice | Papillary thyroid cancer Foci | P value | ||
| None | One | ≥2 | |||
| Concomitant IET: | 0.008 | ||||
| Control | 18 | 0 | 5 | 13 | |
| ICI | 22 | 9 | 4 | 9 | |
| No IET: | 0.70 | ||||
| Control | 19 | 3 | 4 | 12 | |
| ICI | 19 | 5 | 3 | 11 | |
| Pre-existing IET: | 0.07 | ||||
| Control | 21 | 10 | 9 | 2 | |
| ICI | 23 | 8 | 6 | 9 | |
The data are reported both separating by specific ICIs (top) and condensing all ICI-treated animals within the same group (bottom). The P column reports the p value for the χ2 test.
LAG-3, lymphocyte activation gene 3; PD-1, programmed death-1; TIM-3, T-cell immunoglobulin and mucin domain 3 .