Table 1

Comparison of the degrees of tumor-cell killing, enhancement of immune response (in vitro and/or in vivo), toxicity in vivo, and suppression of T cell proliferation among seven commercially available statin drugs

DrugTumor-cell killingEnhancement of immune responseToxicity in vivoSuppression of T cell proliferation
Lovastatin++++–+
Simvastatin++++–++
Fluvastatin++++++N/A
Pitavastatin+++–++N/A
Atorvastatin+–N/AN/A
Rosuvastatin+–N/AN/A
Pravastatin++N/AN/A

  • Factors designated as not applicable were not tested.

  • +++, major effect; +, minor effect; –, no appreciable effect; ++, moderate effect; N/A, not applicable/tested.