Treatment Related Adverse Events
| Adverse event | PexaVec/durvalumab (N=16) | PexaVec/tremelimumab/durvalumab (N=18) | ||||
| Grade 2 | Grade 3 | Grade 4 | Grade 2 | Grade 3 | Grade 4 | |
| Fever | 7 | 9 | 0 | 15 | 3 | 0 |
| Chills | 14 | 0 | 0 | 18 | 0 | 0 |
| Anemia | 7 | 1 | 0 | 6 | 4 | 0 |
| Hypotension | 5 | 0 | 0 | 13 | 1 | 0 |
| Lymphocyte count decreased | 4 | 2 | 2 | 6 | 2 | 4 |
| Sinus tachycardia | 3 | 0 | 0 | 9 | 0 | 0 |
| Alanine aminotransferase increase | 2 | 0 | 0 | 0 | 0 | 0 |
| Aspartate aminotransferase increase | 2 | 0 | 0 | 0 | 0 | 0 |
| Fatigue | 2 | 0 | 0 | 2 | 0 | 0 |
| Headache | 2 | 0 | 0 | 1 | 0 | 0 |
| Hypertension | 2 | 0 | 0 | 2 | 1 | 0 |
| Hypoalbuminemia | 2 | 0 | 0 | 1 | 0 | 0 |
| Nausea | 1 | 0 | 0 | 8 | 0 | 0 |
| Hypophosphatemia | 0 | 0 | 0 | 2 | 3 | 0 |
| Flu-like symptoms | 1 | 0 | 0 | 3 | 0 | 0 |
| Bilirubin increased | 0 | 0 | 0 | 2 | 1 | 0 |
| Dehydration | 0 | 0 | 0 | 2 | 0 | 0 |
| Colitis | 0 | 0 | 0 | 1 | 1 | 0 |
| White blood cell decrease | 1 | 0 | 0 | 1 | 0 | 0 |
| Myositis | 0 | 0 | 0 | 1 | 0 | 0 |
| Neutrophil count decreased | 1 | 0 | 0 | 0 | 0 | 0 |
| Oral pain | 1 | 0 | 0 | 0 | 0 | 0 |
| Pruritus | 1 | 0 | 0 | 0 | 0 | 0 |
| Anorexia | 1 | 0 | 0 | 0 | 0 | 0 |
| Creatinine increased | 1 | 0 | 0 | 0 | 0 | 0 |
| Delirium | 0 | 0 | 0 | 1 | 0 | 0 |
| Dizziness | 0 | 0 | 0 | 1 | 0 | 0 |
| Dyspnea | 0 | 0 | 0 | 0 | 1 | 0 |
| Hypothyroidism | 0 | 0 | 0 | 1 | 0 | 0 |
| Skin rash | 0 | 0 | 0 | 1 | 0 | 0 |