Unique mutations that occurred in tumors from five or more ICI-DM patients
| Gene | Gene name | Chromosome|mutation | Protein change | Top consequence | Number of ICI-DM Patients with mutation (n=13) | Cancer types represented (n=5) |
| NLRC5 | NLR family CARD domain containing 5 | chr16:57025515|SNP:C>T | Pro191Leu | Missense | 9 | 4 |
| DNAJB11 | DnaJ heat shock protein family (Hsp40) member B11 | chr3:186583914|SNP:A>G | Ile264Val | Missense | 7 | 4 |
| PXN | Paxillin | chr12:120216281|SNP:G>C | Pro160Ala | Missense | 7 | 5 |
| XRCC3 | X-ray repair cross complementing 3 | chr14:103699416|SNP:G>A | Thr241Met | Missense | 7 | 4 |
| ERCC6L2 | ERCC excision repair 6 like 2 | chr9:95876006|SNP:A>G | −64+4737A>G | Start lost | 6 | 4 |
| HNRNPUL2 | Heterogeneous nuclear ribonucleoprotein U like 2 | chr11:62715379|Del:ACT…AC>A | c.2163+1_2164-1del | Splice donor variant | 6 | 4 |
| ABCA2 | ATP binding cassette subfamily A member 2 | chr9:137016471|Del:TCT…>T | c.2923+1_2924-1del | Splice donor variant | 5 | 4 |
| ACCS | 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) | chr11:44083431|SNP:C>T | Pro421Leu | Missense | 5 | 3 |
| ANKRD36 | Ankyrin repeat domain 36 | chr2:97192885|Del:CGG…A>C | c.2376+2_2377del | Splice donor variant | 5 | 4 |
| CEMIP2 | Cell migration inducing hyaluronidase 2 | chr9:71745318|SNP:C>T | Arg245Lys | Missense | 5 | 3 |
| EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | chr11:10806814|SNP:C>A | c.107+6G>T | Splice region variant | 5 | 4 |
| ETHE1 | ETHE1 persulfide dioxygenase | chr19:43526349|Del:ACT…AC>A | c.226+1_227-1del | Splice donor variant | 5 | 4 |
| HKDC1 | Hexokinase domain containing 1 | chr10:69266754|SNP:C>A | Asn917Lys | Missense | 5 | 2 |
| ISG20L2 | Interferon stimulated exonuclease gene 20 like 2 | chr1:156727264|SNP:T>C | Asn130Ser | Missense | 5 | 4 |
| KIAA0100 | KIAA0100 | chr17:28628312|SNP:A>C | Val137Gly | Missense | 5 | 4 |
| MAP1S | Microtubule associated protein 1S | chr19:17726616|SNP:C>G | Ser411Cys | Missense | 5 | 4 |
| MED16 | Mediator complex subunit 16 | chr19:868115|SNP:C>T | Glu874Lys | Missense | 5 | 5 |
| MED25 | Mediator complex subunit 25 | chr19:49829947|Del:TGG…A>T | c.688+1_689-1del | Splice donor variant | 5 | 3 |
| MIA3 | MIA SH3 domain ER export factor 3 | chr1:222629034|SNP:A>G | Lys188Arg | Missense | 5 | 4 |
| PON2 | Paraoxonase 2 | chr7:95405463|SNP:G>C | Ser311Cys | Missense | 5 | 4 |
| TANC1 | Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | chr2:159097663|SNP:C>T | Pro30Ser | Missense | 5 | 4 |
| TEP1 | Telomerase associated protein 1 | chr14:20404722|SNP:G>T | Asn307Lys | Missense | 5 | 4 |
| YTHDC1 | YTH domain containing 1 | chr4:68337450|Del:TCT…C>T | c.459+1_460-1del | Splice donor variant | 5 | 4 |
ICI-DM, immune checkpoint inhibitor-induced diabetes mellitus.