Distribution of CD3, CD4, and CD8 T cells in neuroblastoma patient-derived xenografts by positive pixel count analyses
| Treatment | % CD3(+) cells (mean±SD) | P value (vs GD2-EATs) | % CD4(+) cells (mean±SD) | P value (vs GD2-EATs) | % CD8(+) cells (mean±SD) | P value (vs GD2-EATs) | Ratio of CD8 to CD4 T cells | P value (vs GD2-EATs) |
| Unarmed T cells | 1.4±0.7 | 0.05 | 0.8±0.4 | 0.001 | 0.07±0.06 | 0.662 | 0.1±0.07 | 0.96 |
| GD2-EATs | 8.4±2 | – | 6.8±1.3 | – | 1.1±0.3 | – | 0.2±0.06 | – |
| GD2-EATs+BVZ | 24±6 | <0.0001 | 7.4±1.8 | 0.98 | 5±3 | <0.0001 | 1.6±0.6 | 0.001 |
| GD2-EATs+DC101 | 21±4 | <0.0001 | 8.6±3.4 | 0.45 | 4±4 | <0.0001 | 1.7±0.6 | 0.001 |
BVZ, bevacizumab; EAT, T cell armed ex vivo with BsAb.