Table 1

Multiomic features significantly associated with progression-free-survival in univariate analysis. P values are adjusted per Benjamini-Hochberg procedure

VariableHR (95% CI)Adjusted p value
Circulating immune profiling at baseline
 CD56+0.5 (0.32 to 0.78)0.0293
 NK cells0.54 (0.39 to 0.76)0.006
 NK cells/CD56dimCD16+0.56 (0.41 to 0.76)0.006
Circulating immune profiling post pembro
 CD3+0.35 (0.2 to 0.6)0.0018
 CD19+0.71 (0.54 to 0.93)0.0301
 CD19+/HLA-DR+0.71 (0.54 to 0.93)0.0301
 CD56+0.53 (0.33 to 0.87)0.0301
 NK cells0.55 (0.38 to 0.79)0.0061
 NK cells/CD56brCD16dim0.68 (0.49 to 0.94)0.04
 NK cells/CD56dimCD16+0.61 (0.46 to 0.83)0.0061
 Intermediate CD14+CD16+/HLA-DR+++0.62 (0.42 to 0.92)0.0355
 Non-classical CD14dimCD16+0.52 (0.36 to 0.75)0.0039
 Non-classical CD14dimCD16+/HLA-DR++0.56 (0.41 to 0.77)0.0036
 CD16+2.49 (1.29 to 4.84)0.0269
 CD15hi2.44 (1.21 to 4.9)0.0301
 Neutrophils (CD15+CD16+)2.49 (1.28 to 4.83)0.0269
 Eosinophils (CD15+CD16−)0.62 (0.44 to 0.89)0.0301
 Granulo-/HLA-DRdim CD14−0.28 (0.15 to 0.5)0.0008
 Granulocytes (CD15+ or CD16+)2.43 (1.21 to 4.9)0.0301
 Lymphocytes (CD3+ or CD19+ or CD56+)0.32 (0.19 to 0.56)0.001
Gene expression profiling
 CD480.59 (0.47 to 0.75)0.0146
 CD840.59 (0.45 to 0.77)0.0486
 CD2440.74 (0.62 to 0.87)0.0533
 CD3D0.61 (0.47 to 0.8)0.0533
 KLRB10.76 (0.66 to 0.89)0.0533
 CD2762.91 (1.58 to 5.39)0.0653
 ITGA40.54 (0.37 to 0.78)0.0653
 COMP1.22 (1.08 to 1.37)0.0653
 CD690.63 (0.48 to 0.83)0.0653
 CD20.57 (0.42 to 0.79)0.0653
 CCL190.83 (0.74 to 0.93)0.0653
 CD40.63 (0.48 to 0.83)0.0653
 ICOS0.8 (0.7 to 0.92)0.0653
 SH2D1A0.72 (0.6 to 0.87)0.0653
 IRF93.03 (1.52 to 6.02)0.0833
 ZAP700.7 (0.56 to 0.88)0.0889
 PSMB52.17 (1.33 to 3.54)0.0909
 JAK30.64 (0.48 to 0.86)0.098
 CD45RA0 to 85 (0.77 to 0.95)0.098
 PTPRC0.55 (0.38 to 0.81)0.098
 CD1C0.83 (0.74 to 0.94)0.098
Microbiome
LKT_s_Eisenbergiella_massiliensis13.93 (3.51 to 55.33)0.0891
  • COMP, cartilage oligomeric matrix protein; IRF9, interferon-responsive factor 9; KLRB1, killer cell lectin like receptor B1; LKT, last known taxon; NK, natural killer; PSMB5, proteasome 20S subunit beta 5; PTPRC, protein tyrosine phosphatase receptor type C.