Variable | HR (95% CI) | Adjusted p value |
Circulating immune profiling at baseline | ||
CD56+ | 0.5 (0.32 to 0.78) | 0.0293 |
NK cells | 0.54 (0.39 to 0.76) | 0.006 |
NK cells/CD56dimCD16+ | 0.56 (0.41 to 0.76) | 0.006 |
Circulating immune profiling post pembro | ||
CD3+ | 0.35 (0.2 to 0.6) | 0.0018 |
CD19+ | 0.71 (0.54 to 0.93) | 0.0301 |
CD19+/HLA-DR+ | 0.71 (0.54 to 0.93) | 0.0301 |
CD56+ | 0.53 (0.33 to 0.87) | 0.0301 |
NK cells | 0.55 (0.38 to 0.79) | 0.0061 |
NK cells/CD56brCD16dim | 0.68 (0.49 to 0.94) | 0.04 |
NK cells/CD56dimCD16+ | 0.61 (0.46 to 0.83) | 0.0061 |
Intermediate CD14+CD16+/HLA-DR+++ | 0.62 (0.42 to 0.92) | 0.0355 |
Non-classical CD14dimCD16+ | 0.52 (0.36 to 0.75) | 0.0039 |
Non-classical CD14dimCD16+/HLA-DR++ | 0.56 (0.41 to 0.77) | 0.0036 |
CD16+ | 2.49 (1.29 to 4.84) | 0.0269 |
CD15hi | 2.44 (1.21 to 4.9) | 0.0301 |
Neutrophils (CD15+CD16+) | 2.49 (1.28 to 4.83) | 0.0269 |
Eosinophils (CD15+CD16−) | 0.62 (0.44 to 0.89) | 0.0301 |
Granulo-/HLA-DRdim CD14− | 0.28 (0.15 to 0.5) | 0.0008 |
Granulocytes (CD15+ or CD16+) | 2.43 (1.21 to 4.9) | 0.0301 |
Lymphocytes (CD3+ or CD19+ or CD56+) | 0.32 (0.19 to 0.56) | 0.001 |
Gene expression profiling | ||
CD48 | 0.59 (0.47 to 0.75) | 0.0146 |
CD84 | 0.59 (0.45 to 0.77) | 0.0486 |
CD244 | 0.74 (0.62 to 0.87) | 0.0533 |
CD3D | 0.61 (0.47 to 0.8) | 0.0533 |
KLRB1 | 0.76 (0.66 to 0.89) | 0.0533 |
CD276 | 2.91 (1.58 to 5.39) | 0.0653 |
ITGA4 | 0.54 (0.37 to 0.78) | 0.0653 |
COMP | 1.22 (1.08 to 1.37) | 0.0653 |
CD69 | 0.63 (0.48 to 0.83) | 0.0653 |
CD2 | 0.57 (0.42 to 0.79) | 0.0653 |
CCL19 | 0.83 (0.74 to 0.93) | 0.0653 |
CD4 | 0.63 (0.48 to 0.83) | 0.0653 |
ICOS | 0.8 (0.7 to 0.92) | 0.0653 |
SH2D1A | 0.72 (0.6 to 0.87) | 0.0653 |
IRF9 | 3.03 (1.52 to 6.02) | 0.0833 |
ZAP70 | 0.7 (0.56 to 0.88) | 0.0889 |
PSMB5 | 2.17 (1.33 to 3.54) | 0.0909 |
JAK3 | 0.64 (0.48 to 0.86) | 0.098 |
CD45RA | 0 to 85 (0.77 to 0.95) | 0.098 |
PTPRC | 0.55 (0.38 to 0.81) | 0.098 |
CD1C | 0.83 (0.74 to 0.94) | 0.098 |
Microbiome | ||
LKT_s_Eisenbergiella_massiliensis | 13.93 (3.51 to 55.33) | 0.0891 |
COMP, cartilage oligomeric matrix protein; IRF9, interferon-responsive factor 9; KLRB1, killer cell lectin like receptor B1; LKT, last known taxon; NK, natural killer; PSMB5, proteasome 20S subunit beta 5; PTPRC, protein tyrosine phosphatase receptor type C.