Logistic regression analysis for risk factors of steroid-refractory CIP
| Univariate analysis | Multivariate analysis | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Previous ILD (yes vs no) | 3.73 (1.27 to 10.99) | 0.017 | 2.03 (0.46 to 8.93) | 0.348 |
| Previous emphysema (yes vs no) | 2.80 (0.96 to 8.06) | 0.056 | ||
| CIP grade (G3-4 vs G2) | 15.38 (4.20 to 55.56) | <0.001 | 12.05 (2.60 to 55.56) | 0.001 |
| Concurrent infection (yes vs no) | 3.30 (0.96 to 11.36) | 0.058 | ||
| ANC (×109 /L) (>7.16 vs <7.16) | 5.80 (1.91 to 17.64) | 0.002 | 4.29 (1.03 to 17.88) | 0.046 |
| Albumin (g/L) (<33.4 vs >33.4) | 4.83 (1.61 to 14.49) | 0.005 | 2.13 (0.50 to 9.01) | 0.304 |
| Ichikado CT score (>114.2 vs <114.2) | 1.01 (1.00 to 1.03) | 0.090 | ||
ILD, emphysema, CIP initial grade, ANC, concurrent infection, albumin and Ichikado CT score were analyzed in univariate analysis. Previous ILD, CIP grade, ANC and albumin were analyzed in multivariate analysis.
ANC, absolute neutrophil count; CIP, checkpoint inhibitor pneumonitis; ILD, interstitial lung disease.