Demographics | All participants with CRS |
No. of participants | 53 |
Sex | |
Male | 34 (64) |
Female | 19 (36) |
Median age, years, (range) | 15 (4–30) |
Diagnosis | |
ALL | 52 (98.1) |
DLBCL | 1 (1.9) |
Prior HSCT | 36 (68) |
Prior CAR therapy | 33 (62) |
Evaluable for coagulopathy* | 48 |
Data presented as No. (%) unless otherwise indicated.
*Five patients were excluded for evaluation of coagulopathy due to lack of laboratory measurements collected in these patients for the coagulopathy parameters of fibrinogen, ferritin, D-dimer and partial thromboplastin time. These five were among the earliest to be treated in the trial and importantly had no manifestations of bleeding.
ALL, acute lymphoblastic leukemia; CAR, chimeric antigen receptor; CRS, cytokine release syndrome; DLBCL, diffuse large B-cell lymphoma; HSCT, hematopoietic stem cell transplantation; INR, international normalized ratio; LD, lymphodepletion ; LDH, lactate dehydrogenase; PCA, principle component analysis; VGEF, vascular endothelial growth factor.