Characteristic | N (%) (N=23) |
Age, median (range) | 36 (23–70) |
Male | 15 (65) |
Race | |
White | 19 (83) |
Black/African American | 3 (13) |
Other | 1 (4) |
Baseline KPS, median (range) | 90 (80–100) |
Diagnosis | |
Gray zone lymphoma | 1 (4) |
Hodgkin’s lymphoma | 20 (87) |
T-cell lymphoma | 2 (9) |
Stage at diagnosis | |
I | 2 (9) |
II | 6 (26) |
III | 9 (39) |
IV | 6 (26) |
Number of prior therapies, median (range) | 7 (3–12) |
Prior BV | 22 (96) |
Prior checkpoint inhibitor | 16 (70) |
Prior AutoSCT | 17 (74) |
Prior AlloSCT | 10 (43) |
Active disease at treatment | 17 (74) |
Dose level | |
1×108 cells/m2 | 3 (13) |
2×108 cells/m2 | 20 (87) |
Lymphodepletion type | |
Bendamustine | 7 (30) |
Fludarabine/bendamustine | 16 (70) |
CRS status | |
Grade 1 CRS | 4 (17) |
Grade 2 CRS | 1 (4) |
No CRS | 18 (78) |
Response to CAR-T | |
Responder (CR, PR) | 16 (70) |
Non-responder (SD, PD) | 7 (30) |
AlloSCT, allogeneic stem cell transplant; AutoSCT, autologous stem cell transplant; BV, brentuxumab vedotin; CR, complete response; CRS, cytokine release syndrome; KPS, Karnofsky Performance Status; PD, progressive disease; PR, partial response; SD, stable disease.