Table 3

Objective response rates by status of select genes

Gene*All patientsMSS group
Responders, n/NORR, % (95% CI)Responders, n/NORR, % (95% CI)
PIK3CA
 Mutation10/2737.0 (19.4 to 57.6)7/2133.3 (14.6 to 57.0)
 No mutation14/2653.8 (33.4 to 73.4)11/2250.0 (28.2 to 71.8)
PTEN
 Mutation7/1741.2 (18.4 to 67.1)3/933.3 (7.5 to 70.1)
 No mutation17/3647.2 (30.4 to 64.5)15/3444.1 (27.2 to 62.1)
TP53
 Mutation11/2544.0 (24.4 to 65.1)10/2343.5 (23.2 to 65.5)
 No mutation13/2846.4 (27.5 to 66.1)8/2040.0 (19.1 to 63.9)
  • *Hotspot mutations in PIK3CA (oncogene); deleterious mutations in PTEN or TP53 (tumor suppressor genes).

  • MSS, microsatellite stable; ORR, objective response rate.