Parameter | Baseline (n=9) | Month 1 (n=9) | % change from baseline to month 1 | Month 4 (n=7) | % change from baseline to month 4 | |||||
Median (range) | Median (range) | Median (range) | P value | r | Median (range) | Median (range) | P value | r | ||
Markers of bone turnover | CTX, ng/mL | 0.42 (0.13, 1.48) | 0.29 (0.1, 1.33) | −23 (−37, 20) | 0.01 | 0.8 | 0.27 (0.18, 0.93) | 6.7 (−35, 65) | 0.9 | 0.03 |
PINP, µg/L | 38.7 (16.1, 73.6) | 32.4 (19.1, 87.2) | −7.1 (−37, 26) | 0.2 | 0.3 | 40.8 (18.4, 83) | 8.4 (0, 53) | 0.02 | 0.8 | |
OCN, ng/mL | 17.9 (6.3, 22.6) | 14.8 (8.7, 26.6) | −2.4 (−54, 128) | 0.6 | 0.1 | 17.5 (4.4, 33) | 30 (−71, 179) | 0.3 | 0.3 | |
Markers of bone metabolism | Calcium, mmol/L | 2.37 (2.22, 2.46) | 2.36 (2.17, 2.46) | −2.6 (−8, 10) | 0.2 | 0.3 | 2.34 (2.15, 2.52) | −0.4 (−7, 3) | 0.4 | 0.2 |
25(OH) VitD, ng/mL | 30.6 (13.1, 104) | 31 (12.9, 118) | 14.9 (−8, 60) | 0.05 | 0.6 | 34.3 (22.1, 104) | 2.9 (−27, 74) | 0.8 | 0.06 | |
PTH, ng/L | 28 (19.2, 53) | 27 (14, 62) | 0 (−56, 30) | 0.9 | 0.02 | 24.8 (15, 34) | −9.3 (−36, 44) | 0.3 | 0.3 |
CTX, C-terminal telopeptide; OCN, osteocalcin; 25(OH) Vit D, 25-hydroxy vitamin D; PINP, procollagen type I N-terminal propeptide; PTH, parathyroid hormone.