Table 3

Comparison with other studies

StudyGrade of irHepatitisPatientsInterventionOutcome
Tew et al9G3–419 patientsCorticosteroids onlyDays from irHepatitis diagnosis to G1, median 42 (range 8–182)
5 patientsCorticosteroids and second line tacrolimusDays from irHepatitis diagnosis back to G1, median 42 (range 33–135)
Li 202237G3–487 patientsHigh-dose corticosteroidsDays from irHepatitis diagnosis until steroid <10 mg/day, median 60 (range 40–85)
128 patientsLow-dose corticosteroidsDays from irHepatitis diagnosis until steroid dose <10 mg/day, median 44 (range 32–70)
Patrinely et al30Any grade164 patientsCorticosteroids only, 35 patients treated second line, 30 with MMF, 3 tacrolimus, 1 infliximab, 1 MMF+abataceptDays from irHepatitis diagnosis until resolution=median 52
Romanski et al32G3–443 patientsCorticosteroids only, 2 patients treated second line with MMFDays from irHepatitis diagnosis until complete resolution=median 53 (for grade 3), median 68 (for grade 4)
Smith et al33Any grade31 patientsCorticosteroids only, 1 patient second line with infliximabDays from irHepatitis diagnosis until resolution, median 43
G3–4Days from irHepatitis diagnosis until resolution, median 60
Gauci et al29G3–421 patientsCorticosteroids onlyDays from irHepatitis diagnosis until resolution, median 37.5
Riveiro-Barciela et al31G3–428 patientsCorticosteroids only and 10 patients treated second line with MMFDays from irHepatitis diagnosis until resolution, median 45
  • G, grade; irHepatitis, immune-related hepatitis; MMF, mycophenolate mofetil.