Multivariate analysis of the factors associated with overall survival in the SYSMH cohort and the SYSUCC cohort
| Variable | SYSMH cohort (cohort A) | SYSUCC cohort (cohort B) | ||||
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age >60 years vs ≤60 years | 2.003 | 0.977 to 4.107 | 0.058 | 2.947 | 1.718 to 5.057 | 8.72×10–5 |
| Gender Male vs female | 1.854 | 0.735 to 4.674 | 0.191 | 0.674 | 0.271 to 1.674 | 0.395 |
| Tumor size >3 cm vs ≤3 cm | 1.458 | 0.555 to 3.831 | 0.444 | 1.374 | 0.790 to 2.392 | 0.261 |
| Multifocality Multifocal vs unifocal | 1.302 | 0.487 to 2.108 | 0.972 | 0.847 | 0.496 to 1.448 | 0.544 |
| Tumor stage T2–T4 vs Ta–T1 | 3.943 | 1.262 to 12.314 | 0.018 | 1.323 | 0.559 to 3.135 | 0.524 |
| Nodal status N1–N2 vs N0 | 4.347 | 1.921 to 9.837 | 0.0004 | 2.486 | 1.301 to 4.748 | 0.006 |
| Metastatic status M1 vs M0 | 1.007 | 0.326 to 3.114 | 0.990 | 1.482 | 0.511 to 4.297 | 0.469 |
| Histological grade High vs low | 0.672 | 0.229 to 1.968 | 0.468 | 1.711 | 0.786 to 3.725 | 0.176 |
| NNMT+CAFs High vs low | 2.437 | 1.069 to 5.554 | 0.034 | 4.904 | 2.650 to 9.074 | 4.113×10–5 |
Cox proportional hazards regression model. Variables associated with survival by univariate analyses were adopted as covariates in multivariate analyses. Significant p values are shown in bold font. HR>1, increased risk of death; HR<1, decreased risk of death.
.CAFs, cancer-associated fibroblasts; NNMT, nicotinamide N-methyltransferase; SYSMH, Sun Yat-sen Memorial Hospital; SYSUCC, Sun Yat-sen University Cancer Center.