Patient (n = 16) and radiation treatment (n = 51) characteristics

Patients
Male sex13 (81 %)
Age at time of initial brain radiation, median (range)57 years (40 – 85 years)
Ipilimumab dosing
 10 mg/kg2 (13 %)
 3 mg/kg14 (88 %)
Number of ipilimumab treatments, median (range)4 (1 – 17)
Radiation Treatment
 Number of radiation courses per patient, median (range)3 (1–8)
Number of lesions irradiated
 123 (45 %)
 2-315 (29 %)
 >313 (25 %)
Type of radiotherapya
 Whole brain radiation5 (10 %)
 Stereotactic Radiosurgery46 (90 %)
Radiation Dose (Gray), median (range)
 Whole brain radiation36 Gy (20 – 36 Gy)
 Stereotactic Radiosurgeryb22 Gy (18 – 24 Gy)
Location of index lesion
 Skin/subcutaneous tissue/lymph nodes8 (26 %)
 Lung14 (45 %)
 Other9 (29 %)
 None3
 Not imaged / Unknown17

Abbreviations: Gy Gray

aWhole brain treatment given in 2 Gy fractions. Stereotactic radiosurgery treatments were administered in 1–5 fractions

bIf multiple lesions were irradiated to different doses, the mean dose was used for tabulation