Patient characteristics

Characteristics		Total (N = 28)
Characteristics		No. of patients	%
Sex	Male	13	46.4
Sex	Female	15	53.6
Stage at Diagnosis (UICC)	I	1	4.2
	II	9	37.5
	III	3	12.5
	IV	11	45.8
	Missing	4	-
Stage at Diagnosis (ENSAT)	I	1	4.2
	II	9	37.5
	III	4	16.6
	IV	10	41.7
	Missing	4	-
Grade	Low	1	8.3
	High	11	91.7
	Missing	16	-
Metastatic disease	Yes	19	67.9
Metastatic disease	No	9	32.1
Sites of Metastasis	Local Recurrence	4	14.3
	Lymph Node	8	28.6
	Lung	10	35.7
	Liver	8	28.6
	Bone	2	7.1
	Other	3	10.7
Functional Tumors at Diagnosis	Yes	14	50
Functional Tumors at Diagnosis	No	14	50
PD-L1 Expression on Tumor Cell Membrane	<5% (negative)	25	89.3
PD-L1 Expression on Tumor Cell Membrane	≥5% (positive)	3	10.7
PD-L1 Expression in Tumor Infiltrating Mononuclear Cells (TIMC)*	Score = 0 (negative)	8	29.6
	Score > 0 (positive)	19	70.4
		Mean +/− SD	Min, Max
Age at Diagnosis (years)		47.4 +/−13.2	19.8 - 73.7
Tumor size (cm)		10.9 +/−4.4	2.5 -19
Mitosis/10HPF		13.7 +/−13.5	0.2-50

*In 1 patient, the PD-L1 staining in TIMC was not assessable.