Reported IDO inhibitors

AgentMechanismFirst author, year
D-1MTTryptophan mimetic; D isoform of MT; Transcriptional suppressor of IDOMetz 2012 [32]
L-1MTTryptophan mimetic; L isoform of MT; selective IDO1 inhibitorOpitz 201 [39]
MTH-TrpTryptophan mimetic; transcriptional suppressor of IDOOkamoto 2007 [92]
β-carbolinesTryptophan mimetic; IDO and TDO inhibitorEguchi 1984 [93]
Naphthoquinone-basedPharmacophore of natural product annulin B; indole mimetic; IDO inhibitorKumar 2008 [94]
S-allyl-brassininPhytoalexin; indole mimeticGaspari 2006 [95]
S-benzyl-brassininPhytoalexin; indole mimeticGaspari 2006 [95]
5-Bromo-brassininPhytoalexin; indole mimeticBanerjee 2008 [96]
Phenylimidazole-basedComputationally designed synthetic IDO inhibitorKumar 2008 [94]
4-phenylimidazoleHeme ligand in IDO enzymeSono 1989 [97]
Exiguamine ANon-tryptophan analogueHarry 2006 [98]
NSC401366Non-indolic IDO inhibitorVottero 2006 [99]

IDO Indoleamine-2,3-dioxygenase 1, 1MT 1-methyl-DL-tryptophan, MTH-Trp methylthiohydantoin-dl-tryptophan, TDO tryptophan-2,3-dioxygenase