IL-2 pathway genes modulated by Varlilumab stimulation of T cells

Gene SymbolDescription
Induced pathway genes
 CD40LGCD40 Ligand
 IL1RAPInterleukin 1 receptor accessory protein
 IL13Interleukin 13
 ADD2Adducin 2 (beta)
 CTNNA1Catenin (cadherin-associated protein) alpha 1
 TERTTelomerase reverse transcriptase
 LAIR2Leukocyte-associated Ig-like receptor 2
 MYCv-myc Myelocytomatosis viral oncogene homolog (avian)
 LIFLeukemia inhibitory factor
 DUSP6Dual specificity phosphatase 6
 OSMOncostatin M
 CSF2Colony stimulating factor 2 (granulocyte-macrophage)
 IER3Immediate early response 3
 CSF1Colony stimulating factor 1 (macrophage)
 NTRK1Neurotrophic tyrosine kinase receptor type 1
 NFIL3Nuclear factor, interleukin 3 regulated
 IL5Interleukin 5
 GZMBGranzyme B (granzyme 2, CTL-associated serine esterase 1
 XCL1Chemokine (C motif) ligand 1
 IL6Interleukin 6 (interferon beta 2)
 IL10Interleukin 10
 CD300ACD300a molecule
 IL9Interleukin 9
 PRSS23Protease serine 23
 PHLDB2Pleckstrin homology-like domain, family B, member 2
Repressed pathway genes
 CXCR5Chemokine (C-X-C motif) receptor 5
 MYCv-myc Myelocytomatosis viral oncogene homolog (avian)
 APPAmyloid beta (A4) precursor protein
 IL24Interleukin 24