Nominal 1-sided P values for ORR and PFS calculated from logistic and Cox regression, respectively, using signature score as a continuous variable.

Signature	HNSCC		Gastric Cancer
	ORR	PFS	ORR	PFS
IFN-λ	0.005	<0.001	0.077	0.032
TCR signaling	0.071	0.002	0.034	0.024
Expanded immune	0.015	<0.001	0.062	0.049
De novo	0.018	<0.001	0.068	0.037