Relative affinity of binding between the major Fc γRs and IgG Isotypes in human and mouse

HumanMouse
FcγRIgG1IgG2IgG4FcγRIgG1IgG2aIgG2b
I++++-++++I-++++++++
IIaH131+++++++III++++++
R131++++++
IIb++-++IIB++++++++
IIIaV158++++++IV-+++++
F158++-++

Italics indicates an inhibitory receptor. Normal text indicates an activating receptor. Rankings are based on KA x105M−1 for each interaction reported in published studies [1],[5],[6]. ++++ indicates a KA greater than 100 x 105 M−1, +++ indicates a KA between 20 and 99 x 105 M−1, ++ indicates a KA between 1 and 19 × 105 M−1, + indicates a KA between 0.5 and 0.9 × 105 M−1, − indicates a KA that was undetectable or less than 0.5 × 105 M−1 .