Important human cytokine and chemokine receptors in cancer immunotherapy
| Receptor family | Cluster of Designation | Ligands |
|---|---|---|
| Cytokine/Chemokine receptors | ||
| IL-1R | CD121a | IL-1β |
| IL-2Rα | CD25 | IL-2 (high affinity) |
| IL-2/15Rβγ | CD122/CD132 | IL-2/15 (intermediate affinity) |
| IL-7Rα | CD127 | IL-7 |
| c-KIT | CD117 | stem cell factor |
| CCR2 | CD192 | MCP-1 (CCL2) |
| CCR5 | CD195 | MIP-1α, RANTES, MCP-3, MIP5 |
| CCR7 | CD197 | CCL19,CCL21 |
| CXCR1 | CD128 | IL-8 |
| CXCR3 | CD183 | CXCL9-11 |
| CXCR4 | CD184 | CXCL2 |
| CX3CR1 | n/a | Fractalkine |