A concise summary of significant findings from preclinical studies combining immunotherapy with thermal ablation

Significance At A Glance
Radiofrequency AblationSurvivalRechallengeTumor VolumeCytolytic ActivityCD4+ Tumor InfiltrationCD8+ Tumor Infiltration
+CpG B [31]NS
+Ex Vivo Stimulated Dendritic Cells [38, 46]
+Poxviral CEA/TRICOM Vaccine [40]NS
+CC Chemokine Ligand 3 [41]
+Anti-CTLA-4 Antibodies [10]
+Anti-CD25 Antibodies [10]`−
+Anti-PD-1 Antibodies [16]
CryoablationSurvivalRechallengeMHC I PresentationMHC II PresentationCD4+ Tumor InfiltrationCD8+ Tumor Infiltration
+CpG ODN [12]
+Ex Vivo Immature Dendritic Cells [37]
+ TLR7 Agonist Imiquimod [11]
Anti-CTLA-4 Antibodies [10, 15]
Anti-CD25 Antibodies [10]
+Cyclophosphamide [44]
Microwave AblationSurvivalRechallengeTumor VolumeTh1/Th2 Cytokine RatioCD4+ Tumor InfiltrationCD8+ Tumor Infiltration
+OK 432 [42]
+GM-CSF Microspheres [45]
+GM-CSF Microspheres & Anti-CTLA-4 Antibodies [45]

↑ Significantly improved response (p < 0.05), ↓ significant decrease (p < 0.05), NS not significant