Relative gene expression of the 15 genes comprising the pre-treatment signature comparing responders in the discovery dataset to healthy volunteers and to non-responders

15-Gene Pre-Treatment ModelPredictor or Enhancer VariableBlood BankDifference Normals versus RespondersPhase 3 Discovery Dataset
N = 50N = 28N = 182Difference
Healthy NormalsRespondersNon-RespondersResponders vs Non-responders
Responders Equivalent to Normals
 ITGA4Predictor14.20.0214.2214.610.39
 LARGEPredictor22.00.0922.0922.970.88
 CDK2Predictor19.60.0919.6919.910.22
 TIMP1Enhancer15.00.1015.114.95−0.15
 DPP4Predictor18.50.1218.6218.950.33
 NRASPredictor17.10.1317.2317.440.21
 ERBB2Predictor23.0−0.1822.8223.230.41
 NAB2Predictor20.0−0.2919.7120.040.33
Responders Upregulated Compared to Normals
 ADAM17Enhancer18.50.3218.1818.360.18
 RHOCEnhancer16.90.3916.5116.630.12
 TGFB1Enhancer13.40.4512.9513.050.10
 CDKN2APredictor21.40.6320.7721.160.39
Responders Downregulated Compared to Normals
 HLADRAEnhancer12.10.4812.5812.640.06
 MYCEnhancer17.70.8218.5318.670.14
Measurement of Gene Expression Not Available
 ICOSPredictorN/AN/A22.3222.780.46