CART72 levels in tumor biopsies

Patient ID	CART72 delivery	Tumor biopsy location	Timing of biopsy	CC49-ζ by PCR (copies/106 cells)
Patient ID	CART72 delivery	Tumor biopsy location	Timing of biopsy	Tumor	Blood
303D	HA	Liver	Day of 4th infusion	220	1937
301B	HA	Liver	2 weeks post 4th infusion	<50	<117
201A	IV	Rectum	Day of 5th infusion	<50	1704

HA hepatic artery, IV intravenous, PCR polymerase chain reaction

Levels of CC49-ζ modified CART72 cells were measured by PCR in tumor biopsies taken at variable time points post-CART72 infusion in three patients. CC49-ζ levels in biopsied tumor tissue were compared to levels in blood at corresponding time points. Patients 303D and 301B were treated in trial C-9702 and patient 201A was treated in trial C-9701