CART72 levels in tumor biopsies

Patient IDCART72 deliveryTumor biopsy locationTiming of biopsyCC49-ζ by PCR (copies/106 cells)
303DHALiverDay of 4th infusion2201937
301BHALiver2 weeks post 4th infusion<50<117
201AIVRectumDay of 5th infusion<501704

HA hepatic artery, IV intravenous, PCR polymerase chain reaction

Levels of CC49-ζ modified CART72 cells were measured by PCR in tumor biopsies taken at variable time points post-CART72 infusion in three patients. CC49-ζ levels in biopsied tumor tissue were compared to levels in blood at corresponding time points. Patients 303D and 301B were treated in trial C-9702 and patient 201A was treated in trial C-9701