Multivariate Cox proportional hazard analysis for DFS and OS of patients with non-metastatic invasive breast cancer

DFSOS
Hazard RatioP95.0% CI for HR (range)Hazard RatioP95.0% CI for HR (range)
 TNM stageb2.1800.0091.219–3.8983.9370.0061.494–10.371
 Signaturesb1.5600.1380.866–2.8102.0850.0910.889–4.890
Model before stepwise selection
 Agea1.0310.9480.411–2.5894.3910.1880.486–39.703
 T statusb2.6130.0101.255–5.4393.6790.0281.148–11.793
 N stageb1.2220.5120.671–2.2251.1250.8150.420–3.010
 Gradeb1.1420.7500.504–2.5854.1890.0271.180–14.867
 HER-2/neu0.9280.8840.342–2.5200.0660.0160.007–0.606
 Hormone Receptors0.2770.0040.277–0.6690.1680.0070.046–0.621
 Signaturesb2.0630.0411.031–4.1264.8500.0141.374–17.122
Model after stepwise selection
 T statusb2.9990.0011.602–5.6153.5220.0051.477–8.398
 Hormone Receptors0.2690.0020.116–0.6210.2310.0140.072–0.742
 Signaturesb2.1460.0271.091–4.2194.2730.0061.521–11.999

aAge under 50 and over 50 years old

bAll categorical covariates were transformed into numeric codes as follows : T status (T1; 1, T2; 2, T3; 3), N stage (N0; 0, N1; 1, N2; 2, N3; 3), Grade (G1; 1, G2; 2, G3; 3), Signatures (FCIS; 1, Rest; 2, UCIS; 3) TNM stage (I; 1, II; 2, III; 3)