Demographic and disease characteristics

Characteristics/VariableNo. of patients (%)
Age
 Median61.5
 Range49–81
Sex
 Female2 (16.7)
 Male10 (83.3)
ECOG (screening)
 Grade 010 (83.3)
 Grade 12 (16.7)
Time from diagnosis to treatment1.0 month (Mdn)
Metastatic disease11 (91.7)
Histologic subtypes
 Clear cell11 (91.6)
 Non-clear cell (papillary)1 (8.4)
 Sarcomatoid features6 (50)
Fuhrman nuclear grade
 Grade 12 (16.7)
 Grade 37 (58.3)
 Grade 43 (25.0)
MSKCC [38] and/or IMDC [39] variables
  < 1 year from diagnosis to targeted treatment11 (100)
 Karnofsky performance status <80%1 (9.1)
 Haemoglobin < LLN8 (72.7)
 Serum corrected calcium conc. > ULN5 (45.5)
 Lactate dehydrogenase >1.5 x ULN1 (9.1)
 Neutrophil count > ULN0 (0)
 Paltelet count > ULN3 (27.2)
MSKCC prognostic group
 Favourable0 (0)
 Intermediate5 (45.5)
 Poor6 (54.5)
IMDC prognostic group
 Favourable0 (0)
 Intermediate6 (54.5)
 Poor5 (45.5)

Abbreviations: LLN lower limit of normal, ULN upper limit of normal, MSKCC Memorial Sloan-Kettering Cancer Center, IMDC International Metastatic RCC Database, Mdn median