Select ongoing and pending clinical trials that allow prior treatment with a PD-1 or PD-L1 inhibitor

Clinicaltrials.gov identifier	Experimental agents	Regimen targets	Phase	Tumor type
NCT02899078	Nivolumab + Ibrutinib	PD-1 + BTK	1b/2	RCC
NCT02923531	Nivolumab + X4P-001	PD-1 + CXCR4	1b/2a	RCC
NCT02963610*	Pembrolizumab + Lenalidomide	PD-1 + immunomodulatory	1/2	NSCLC
NCT03083808	Pembrolizumab + Docetaxel/Pemetrexed/Gemcitabine	PD-1 + Chemotherapy	2	NSCLC
NCT03041181	Nivolumab + Docetaxel	PD-1 + Chemotherapy	2	NSCLC
NCT02437136	Pembrolizumab + Entinostat	PD-1 + HDAC	1b/2	NSCLC and melanoma
NCT02959437	Pembrolizumab + Azacitidine + Epacadostat	PD-1 + Chemotherapy + IDO-1	1/2	NSCLC**
NCT03084640	Pembrolizumab + CMP-001	PD-1 + TLR9	1b/2	melanoma
NCT03014648	Atezolizumab	PD-L1	2	NSCLC

PD-1 programmed cell death protein 1, BTK: Bruton’s tyrosine kinase, RCC: renal cell carcinoma, CXCR4: C-X-C chemokine receptor type 4, NSCLC: non-small cell lung cancer, HDAC: histone deacetylases, IDO-1: Indoleamine 2,3-Dioxygenase 1, TLR9: Toll-like receptor 9, PD-L1 programmed death-ligand 1

*Prior treatment with anti-PD-1/PD-L1 is only allowed for the Phase 2 portion of this trial (which is only for NSCLC patients)

**Only the NSCLC cohort allows prior treatment with PD-1/PD-L1

Please note that this table was constructed using the following search terms on clinicaltrials.gov on 5/12/2017: “Nivolumab AND previously treated”, “Pembrolizumab AND previously treated”, and “Atezolizumab AND previously treated”. After generating a list of trials, the eligibility criteria for each trial was manually screened for inclusion in this table