Class | Target | Compound | Clinical phase | Sponsor | Indication | ClinicalTrials.gov identifier | Status/ Results | Reference |
---|---|---|---|---|---|---|---|---|
Small molecules | CSF1R (and cKIT, Flt3) | Pexidartinib (PLX3397, PLX108-01) | 1 | Plexxikon | Solid tumors and extension for MEC, dt-GCT, GIST, ATC, metastatic solid tumors | NCT01004861 | OngoingORR: 12/23 (52%)CBR: 19/23 (83%) | [22] |
3 | Plexxikon/Daiichi Sankyo | dt-GCT or GCT-TS | NCT02371369 | Ongoing | - | |||
Monoclonal antibodies | CSF1R | Emactuzumab (RG7155) | 1 | Roche | Solid tumors and dt-GCT | NCT01494688 | ORR: 24/28 (86%)CBR: 27/28 (96% | [12] |
CSF1R | Cabiralizumab (FPA008) | 1/2 | FivePrime | dt-GCT | NCT02471716 | Ongoing | - | |
CSF1 | MCS110 | 2 | Novartis | dt-GCT or GCT-TS | NCT01643850 | OngoingORR: 4/4 (100%) | [21] |
ATC anaplastic thyroid cancer, CBR clinical benefit rate, CSF1 colony-stimulating factor 1, CSF1R colony-stimulating factor 1 receptor, dt-GCT diffuse-type tenosynovial giant cell tumor, GCT-TS giant cell tumor of the tendon sheath, GIST gastrointestinal stromal tumor, MEC mucoepidermoid carcinoma of the lung, ORR objective response rate