Pharmacokinetics of pembrolizumab at steady state of regimens of 2 mg/kg Q3W, 200 mg Q3W, 10 mg/kg Q3W and 10 mg/kg Q2W. Based on pooled cross-study data [n, Mean (%CV), Median (10-90 percentile)]

PK Value (unit)Dose RegimenNMean (%CV)Median10–90 Percentile
Cmax(mcg/mL)2 mg/kg Q3W75568.0 (24%)66.348.3–88.2
200 mg Q3W83093.4 (26%)89.166.4–124.3
10 mg/kg Q3W1403360.3 (23%)357.6257.7–466.8
10 mg/kg Q2W652459.3 (25%)457.7315.9–599.9
Ctrough(mcg/mL)2 mg/kg Q3W75522.2 (48%)21.19.18–35.7
200 mg Q3W83029.7 (47%)27.614.9–46.2
10 mg/kg Q3W1403126.4 (44%)120.459.8–200.2
10 mg/kg Q2W652220.9 (39%)217.8111.8–325.3
AUCss, 0-6-weeks(mcg*day/mL)2 mg/kg Q3W7601376.5 (38%)1316.5724.9–2038.5
200 mg Q3W8301871.1 (37%)1787.01120.6–2730.9
10 mg/kg Q3W14057625.4 (35%)7436.04354.0–11172.8
10 mg/kg Q2W65212002.7 (34%)11993.56834.7–16895.5