Cmax(mcg/mL) | 2 mg/kg Q3W | 755 | 68.0 (24%) | 66.3 | 48.3–88.2 |
200 mg Q3W | 830 | 93.4 (26%) | 89.1 | 66.4–124.3 |
10 mg/kg Q3W | 1403 | 360.3 (23%) | 357.6 | 257.7–466.8 |
10 mg/kg Q2W | 652 | 459.3 (25%) | 457.7 | 315.9–599.9 |
Ctrough(mcg/mL) | 2 mg/kg Q3W | 755 | 22.2 (48%) | 21.1 | 9.18–35.7 |
200 mg Q3W | 830 | 29.7 (47%) | 27.6 | 14.9–46.2 |
10 mg/kg Q3W | 1403 | 126.4 (44%) | 120.4 | 59.8–200.2 |
10 mg/kg Q2W | 652 | 220.9 (39%) | 217.8 | 111.8–325.3 |
AUCss, 0-6-weeks(mcg*day/mL) | 2 mg/kg Q3W | 760 | 1376.5 (38%) | 1316.5 | 724.9–2038.5 |
200 mg Q3W | 830 | 1871.1 (37%) | 1787.0 | 1120.6–2730.9 |
10 mg/kg Q3W | 1405 | 7625.4 (35%) | 7436.0 | 4354.0–11172.8 |
10 mg/kg Q2W | 652 | 12002.7 (34%) | 11993.5 | 6834.7–16895.5 |