Response by irAE and Disease Type

Best ResponsemMmRCC
irAE, n = 84No irAE, n = 539irAE, n = 46No irAE, n = 873
Complete Response (CR)5(6.0%)23(4.3%)3 (6.5%)44(5.0%)
Partial Response (PR)27 (32.1%)89 (16.5%)10 (21.7%)153 (17.5%)
Stable Disease (SD)29 (34.5%)167 (31.0%)19 (41.3%)317 (36.3%)
Progressive Disease (PD)19 (22.6%)211 (39.1%)13 (28.3%)262 (30.0%)
Missing4 (4.8%)49 (9.1%)1 (2.2%)97 (11.1%)
CR + PR (n,%)32 (38.1%)112 (20.8%)aP = 0.005813 (28.3%)197 (22.6%)aP = 0.5999
CR + PR+ SD (n, %)61 (72.6%)279 (51.8%)bP = 0.001332 (69.6%)514 (58.9%)bP = 0.6263

aFisher’s exact test comparing best response by irAE

bFisher’s exact test comparing tumor control by irAE