Treatment Related Adverse Events occurring in > 10% of subjects OR ≥ grade 3
| Adverse events | Grade 1–2 | Grade 3 | Grade 4 |
|---|---|---|---|
| Fatigue | 23 (65.7%) | 1 (2.9%) | |
| Nausea | 20 (57.1%) | ||
| Anorexia | 11 (31.4%) | ||
| Vomiting | 11 | 1 | |
| Edema | 10 (28.6%) | ||
| Anemia | 8 (22.9%) | 1 | |
| Diarrhea | 8 | ||
| Rash | 8 | 1 | |
| Shortness of breath | 7 (20%) | ||
| Constipation | 5 (14.3%) | ||
| Thrombocytopenia | 4 (11.4%) | ||
| Fever | 1 | ||
| Hypoglycemia | 1 |