Safety and efficacy of HIV positive patients treated with immune checkpoint inhibitors

StudyNo of patients with HIVDiseaseViral responseDisease response
Rai et al. 2017 [20]118 Melanoma, 1 HCC, 1 RCC, 1 BCNo pt. had loss in viral control or immune reconstitution inflammatory syndrome2 CR, 1 PR, 4 SD, 4PD
Heppt et al. 2017 [19]10MelanomaNo increase in viral load, no effect on CD4 count
Wightman et al. 2015 [18]1MelanomaImproved CD4 count and decrease in Viral loadNA
Burke et al. 2011 [9]1MelanomaStable CD 4 count and viral loadPR
Morris et al. 2017 [14]2Anal cancerStable CD4 count and viral loadNA
Sandoval-Sus et al. 2017 [16]1Hodgkin lymphomaStable CD4 count and viral loadPR
Tomsitz et al. 2017 [17]1MelanomaStable CD4 count and viral loadPR
Ruzevick et al. 2013 [15]1MelanomaStable CD4 count and viral loadPR
Davar et al. 2015 [10]1MelanomaStable CD4 count and viral loadPD
Le Garff et al. 2017 [12]1NSCLCCD4 count increased with stable viral loadPD
Guihot et al. 2017 [6]1NSCLCStable CD4 count and viral loadPR
Samri et al. 2017 [7]12NSCLCStable CD4 count and viral load3 PR, 4 SD, 5 PD
Hentrich et al. 2017 [11]1NSCLCCD4 count decreased but viral load remained stablePD
McCullar et al. 2017 [13]1NSCLCCD4 count decreased but viral load remained stableCR
Uldrick et al. 2017 (NCT02595866)17MixIncrease in CD4 count, viral load remained suppressedNA

Abbreviations: HCC hepatocellular carcinoma, RCC renal cell carcinoma; BC bladder carcinoma, CR complete response, PR partial response, SD stable disease, PD progressive disease, NSCLC non-small cell lung cancer