Age and gender distribution of selected patients

		anti-CTLA-4		anti-PD-1
		responders	non-responders	responders	non-responders
Age	< 30	0	1	0	0
	30–39	0	1	2	0
	40–49	1	4	2	2
	50–59	3	0	6	6
	60–69	4	5	4	6
	> 70	2	3	7	5
	Ave. age (years)	62.3	56.4	61.3	61.4
	STDEV (years)	10.9	17.7	15.3	11.6
	p value (U test)	0.35		0.81
Gender	Female	4	4	8	7
Gender	Male	6	10	13	12
Clinical response	CR	0		2
	PR	2		12 (3 borderline CR)
	SD	8		7
	PD		14		19

Age and gender distribution of patients in the anti-CTLA-4 and anti-PD-1 cohorts in relation to clinical response are shown. More details regarding patient sample selection can be found in the Materials and Methods section. p values shown are from U test between responders and non-responders. p < 0.05 was considered statistically significant