Tumor genomic next generation sequencing (NGS) study reveals mutations in several genes, including somatic mutations in genes mutated in the sebaceous carcinoma COSMIC dataset (in bold)

GeneAlterationSubcellular localizationPathway
LRP1BG3156C, Q1125*Plasma membraneReceptor mediated endocytosis
CCND1S41LNucleus; cytosolCyclin D1, cell cycle
TET2P174HNucleoplasmDNA demethylation
TP53rearrangement, del exon 10-11NucleoplasmDNA repair
FANCAA816V, R685SNucleusDNA repair
FGF6A63TExtracellularGrowth factor
MYST3Q1681_Q1684delNucleolus; cytosolHistone acetyltransferase (HAT)
KRASG12CCytosolMAPK signalling
RBM10F173fs*7NucleusmRNA splicing
METamplificationPlasma membraneReceptor tyrosine kinase
FGFR3I539delEndoplasmic reticulumReceptor tyrosine kinase
FLT4K520E, R658WNucleus; plasma membraneReceptor tyrosine kinase
ROS1N692HVesiclesReceptor tyrosine kinase
TERT-124C>TNucleoplasmTelomerase
WT1R471SNucleoplasmWT1 Transcription Factor
MYCL435FNucleoplasmMYC Transcription Factor
ZNF703G406RNucleusTranscriptional co-repressor
c11orf30C1211SNucleoplasmTrascriptional Repressor
FLCNR320QNucleus; cytosolTumor suppressor
TNFAIP3R706QCytosolUbiquitination

*denotes mutations causing a premature stop codon

fs denotes the presence of a frameshift mutation