Association between TILs and other immunological biomarkers in the primary cohort (n = 95)

Biomarker	CD8 rich (n = 56)	CD8 poor (n = 39)	P value	CD4 rich (n = 76)	CD4 poor (n = 19)	P value
Biomarker	No. of patients	No. of patients		No. of patients	No. of patients
Foxp3			0.002			0.010
≥ 1%	37	13		45	5
< 1%	19	26		31	14
CD33			0.682			0.119
≥ 1%	38	28		50	16
< 1%	18	11		26	3
PD-1			0.919			0.470
≥ 1%	25	17		35	7
< 1%	31	22		41	12
PD-L1-TC			0.555			0.581
≥ 1%	19	11		23	7
< 1%	37	28		53	12
PD-L1-TC			0.745			0.359
≥ 10%	10	8		13	5
< 10%	46	31		63	14
PD-L1-IC			0.026			0.316
≥ 1%	22	7		25	4
< 1%	34	32		51	15
Tim-3			0.040			0.245
≥ 1%	26	10		31	5
< 1%	30	29		45	14
LAG3			0.047			0.064
≥ 1%	13	3		16	0
< 1%	43	36		60	19
OX40			0.535			0.107
≥ 2%	42	27		58	11
< 2%	14	12		18	8
ICOS			0.200			0.354
≥ 6%	29	15		37	7
< 6%	27	24		39	12
IDO1-TC			0.441			0.679
≥ 1%	26	15		32	9
< 1%	30	24		44	10
IDO1-IC			0.616			0.172
≥ 6%	17	10		24	3
< 6%	39	29		52	16

TILs tumor infiltrating lymphocytes, TC tumor cell, IC immune cell

All entries in boldface are below 0.05