Overall Best Response Per RECIST V 1.1 and for Patients with Metformin Duration of > 5 Months (PR = Partial Response, CR = Complete Response, SD = Stable Disease, PD = Progressive Disease, ORR = Objective Response Rate, DCR = Disease Control Rate)
| All Patients | No Metformin N = 33 (60%) | Metformin N = 22 (40%) | |
|---|---|---|---|
| Best Response | |||
| PR | 14 (42.4%) | 9 (40.9%) | P = 0.39 |
| CR | 4 (12.1%) | 6 (27.27%) | |
| SD | 2 (6%) | 2 (9.1%) | |
| PD | 13 (39.4%) | 5 (22.7%) | |
| ORR | 54.5% | 68.2% | P = 0.31 |
| DCR | 60.6% | 77.3% | P = 0.19 |
| Median Time to Achieve Best Response (months) | 2.7 | 2.8 | P = 0.12 |
| Metformin Duration of > 5 Months | No Metformin N = 33 (67.3%) | Metformin N = 16 (32.7%) | |
| Best Response | |||
| PR | 14 (42.4%) | 5 (31.2%) | P = 0.12 |
| CR | 4 (12.1%) | 6 (37.5%) | |
| SD | 2 (6%) | 2 (12.5%) | |
| PD | 13 (39.4%) | 3 (18.8%) | |
| ORR | 54.5% | 68.7% | P = 0.34 |
| DCR | 60.6% | 81.3% | P = 0.14 |
| Median Time to Achieve Best Response (months) | 2.7 | 3 | P = 0.11 |