Parameter | Description | Value | Reference |
---|---|---|---|
Physiological Parameters | |||
% of macrophages per tumor total cells | 10% | Calibrated to match [11] | |
TEM-driven tumor neovasculature increase | 4-fold | [12] | |
TEM portion of differentiated macrophages | 55–70% | [13] | |
M2/M1 ratio in highly metastatic tumors | 2.06 | [47] | |
M2/M1 ratio in moderately metastatic tumors | 0.77 | [47] | |
Vessel Radius-Associated Parameters Related to TEM Effects | |||
ks | Natural shrinking tendency of vessel radius | 2.24 | [39] |
kPC | Response rate of radius to tumor pressure | 0.76 | [39] |
Macrophage-Associated Parameters Related to Tumor Growth | |||
λM | Tumor native proliferation rate (day−1) | 0.5 | Calibrated to match [11] |
λOL | Recovery rate of quiescent oxygen level | 0.05(*) | Calibrated to match [36] |
λOT | M2 induced lowering viable O2 threshold rate | 200 /s | Calibrated to match [36] |
λrec | Recovery rate of λM2to zero | 0.1(*) | Calibrated to match [36] |
λF | M2 induced proliferation rate | 1000 /s | Calibrated to match [36] |
λNO | M1 nitric oxide induced death rate | 3 /s | Calibrated to match [8] |
GN | Cell degradation rate in the necrotic region | 0.3(*) | Calibrated to match [11] |
Macrophage Differentiation Scaling Coefficients | |||
kM1 | Differentiation of M1 macrophage | 20 | [36] |
kM2 | Differentiation of M2 macrophage | 20 | [36] |
kT2 | Differentiation of TEM | 8.21 | [13] |
kAng2 | Effect of Ang2 on TEM differentiation | 0.95 | Calibrated to match [1, 13] |
kT2M2 | Effect of IL-10 on M2 differentiation | 0.006 | Calibrated to match [47] |
Macrophage Movement Scaling Coefficients | |||
MO | Effect of oxygen on macrophage movement | 1000 | [11] |
MP | Effect of oxygen on macrophage movement | 350 | [11] |
MC | Chemotactic macrophage movement | 500 | [11] |
MAng2 | Effect of Ang2 on TEM movement | 1000 | Calibrated to match [16] |
(*) Value is non-dimensionalized by the diffusivity of oxygen [68] (1 × 10−5 cm2 s−1)