Cytokines influenced (alteration>2folds) by AGT silence
| Cytokines | Functions |
|---|---|
| Immune-activating | |
| IL-7 | Necessary for both B-cell and T-cell proliferation [43]. |
| IL-20 | Enhancing innate and adaptive immunity [44]. |
| CD40 ligand | A potent dendritic cell activation molecule, counteracting immune escape mechanisms in the tumor microenvironment [45, 46]. |
| CXCL1 | Pro-inflammatory cytokine: the activation and regulation of innate and adaptive immunity [53]. |
| CXCL11 | Chemotactic for activated T cells [47]. |
| CXCL14 | Attraction of dendritic cells [48] |
| TNFSF14 | Stimulating lymphocyte proliferation and tumor cell-specific anti-tumor immune responses [49]. |
| Immunosuppressive | |
| IL-3 | Promoting dendritic cells secreting significantly less IL-12 p70 and more IL-10 [54] |
| IL-4 | Participating in both TAM and MDSC survival and the acquisition of an immune-suppressive phenotype [55, 56]. |
| IL-10 | Inhibiting the ability of APCs to present antigens to T cells [57] |
| Fas | Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58] |
| Fas ligand (FASL) | Inducing apoptosis of cytotoxic T lymphocytes through the FAS-FASL pathway [58] |
| CCL1 | Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege [59] |
| CCL7 | Chemoattracting MDSCs and Tregs in tumor microenvironment [60]. |
| SDF-1 | Increasing immunological tolerance by polarizing Tregs [61]. |
| CCL28 | Recruiting Tregs in tumor hypoxia microenvironment [62]. |
| G-CSF | Recruiting MDSCs in tumor hypoxia microenvironment [63]. |
| GM-CSF | Shaping the tumour microenvironment by promoting myelopoiesis and recruitment of suppressive myeloid cells [55, 64, 65] |
| Eotaxin-2 | the recruitment and polarization of Tregs [66, 67]. |
| TNFSF12 | Curtailing the innate response and its transition to adaptive TH1 Immunity [68]. |