Overall Survival statistical summary

Variable		Total	Univariate Cox models				Multivariate Cox models
			Univariate Cox models				Clinical model				Clinical and CD8 model				Clinical and HLA model				Clinical and HLA/CD8 model
			Hratio	95% IC	p	adj padj padj p	Hratio	95% IC	p	adj padj padj p	Hratio	95% IC	p	adj padj padj p	Hratio	95% IC	p	adj padj padj p	Hratio	95% IC	p	adj padj padj p
Age (%)	median (range)	63 (29–83)	1.015	[0.993;1.038]	0.18	0.42	1.018	[0.995;1.041]	0.13	0.36	1.012	[0.990;1.035]	0.3	0.57	1.016	[0.993;1.040]	0.17	0.42	1.015	[0.993;1.039]	0.18	0.42
continuous	mean(sd)	61.73 (11.47)	1.015	[0.993;1.038]	0.18	0.42	1.018	[0.995;1.041]	0.13	0.36	1.012	[0.990;1.035]	0.3	0.57	1.016	[0.993;1.040]	0.17	0.42	1.015	[0.993;1.039]	0.18	0.42
Sex(%)	Female	33 (28.95)	1				1				1				1				1
	Male	81 (71.05)	0.762	[0.469;1.238]	0.27	0.55	0.77	[0.464;1.282]	0.32	0.57	0.771	[0.460;1.292]	0.32	0.57	0.759	[0.447;1.289]	0.31	0.57	0.686	[0.397;1.185]	0.18	0.42
Chemo(%)	No	36 (31.58)	1				1				1				1				1
	Yes	78 (68.42)	0.812	[0.502;1.314]	0.4	0.6	0.73	[0.432;1.231]	0.24	0.53	0.928	[0.534;1.612]	0.79	0.92	0.744	[0.438;1.262]	0.27	0.55	0.793	[0.464;1.355]	0.4	0.6
KRAS	No	79 (69.30)	1				–				–				–				–
	Yes	35 (30.70)	1.979	[1.211;3.233]	0.006	0.05	–				–				–				–
BRAF+KRAS	No	76 (66.67)	1				1				1				1				1
	Yes	38 (33.33)	1.737	[1.07;2.82]	0.03	0.13	2.06	[1.223;3.487]	0.007	0.05	2.171	[1.281;3.682]	0.004	0.05	1.882	[1.104;3.230]	0.02	0.1	1.716	[0.992;2.968]	0.05	0.2
Tumor side	Right	25 (21.93)	1				1				1				1		1		1
	Left	89 (78.07)	0.92	[0.528;1.604]	0.77	0.91	1.304	[0.721;2.359]	0.38	0.6	1.151	[0.639;2.074]	0.64	0.79	1.334	[0.735;2.421]	0.34	0.58	1.208	[0.671;2.175]	0.53	0.7
CD8 invasive margin continuous			0.66	[0.500;0.866]	0.003	0.05					0.644	[0.477;0.869]	0.004	0.05
CD8 tumor core continuous			0.906	[0.679;1.209]	0.5	0.67
CD8 total continuous			0.705	[0.534;0.926]	0.01	0.06
HLA score		41 (37.27)	1												1
		69 (62.73)	0.593	[0.366;0.959]	0.03	0.13									0.631	[0.379;1.050]	0.08	0.25
HLA/CD8 combined	Low/Low	24 (21.82)	1																1
	Others	86 (78.18)	0.391	[0.230;0.663]	0.0005	0.02													0.415	[0.234;0.737]	0.003	0.05
PDL1 TC SP142	High	18	1
	Low	5 (4.39)	0.6	[0.147;2.443]	0.48	0.66
PDL1 invasive margin SP142	High	34 (29.82)	1
	Low	80 (70.18)	0.791	[0.463;1.348]	0.39	0.6
CD163 invasive margin	1	27 (23.68)	1
	2	42 (36.84)	0.719	[0.408;1.266]	0.25	0.54
	3	32 (28.07)	0.807	[0.443;1.467]	0.48	0.66
FoxP3 invasive margin	0	45 (39.47)	1
	1	20 (17.54)	1.182	[0.654;2.135]	0.58	0.73
NKp46	Low	50 (49.50)	1
	High	45 (50.50)	1.024	[0.640;1.636]	0.93	0.98
AUC		–	–				0.63				0.72				0.67				0.72