Association of Baseline Blood Biomarkers and Outcomes
| Multivariate Model for PFS | Multivariate Model for OS | |||
|---|---|---|---|---|
| Biomarker | HR (95% CI)a, N = 157 | P Valuea | HR (95% CI)a, N = 157 | P Valuea |
| WBC | 1.01 (0.97–1.05) | .68 | 1.04 (0.99–1.09) | .10 |
| ANC | 1.01 (0.97–1.06) | .55 | 1.04 (1.00–1.09) | .08 |
| ANC ≥ 7.5 | 1.05 (0.68–1.63) | .81 | 1.86 (1.09–3.19) | .02 |
| ALC | 0.78 (0.56–1.10) | .15 | 0.86 (0.56–1.31) | .48 |
| ANC/ALC | 1.04 (1.02–1.06) | <.001 | 1.04 (1.02–1.06) | <.001 |
| ANC/ALC ≥ 5.9 | 1.61 (1.14–2.28) | .008 | 1.87 (1.16–3.02) | .01 |
| AMC ≥ 0.63 | 1.50 (1.06–2.12) | .02 | 1.59 (0.88–2.90) | .13 |
| AEC | 0.43 (0.15–1.29) | .13 | 1.71 (1.06–2.75) | <.03 |
| Platelets (per 50 unit increase) | 1.03 (0.95–1.11) | .48 | 0.29 (0.06–1.55) | .15 |
| M:L | 1.04 (1.02–1.06) | <.001 | 1.05 (0.95–1.15) | .34 |
| M:L ≥ 11.3 | 1.36 (0.91–2.03) | .13 | 1.04 (1.02–1.06) | <.001 |
aHRs, 95% CI, and P values result from single variable (ie, unadjusted) Cox proportional hazard models. Multivariable models were adjusted for age at diagnosis, sex, ECOG, and number of lines of chemotherapy for OS; adjusted for age at diagnosis and sex for PFS