Adverse events (n = 17)
| Adverse Event | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Hematology | ||||
| Anemia | 3 | 2 | 4 | 0 |
| Leukopenia | 4 | 1 | 1 | 0 |
| Lymphopenia | 0 | 2 | 1 | 1 |
| Neutropenia | 0 | 0 | 1 | 0 |
| Thrombocytopenia | 3 | 0 | 1 | 0 |
| Gastrointestinal Disorders | ||||
| Abdominal pain | 1 | 0 | 0 | 0 |
| Anorexia | 1 | 1 | 0 | 0 |
| AST increased | 1 | 0 | 0 | 0 |
| Bloating | 0 | 1 | 0 | 0 |
| Dysgeusia | 0 | 1 | 0 | 0 |
| Dyspepsia | 2 | 0 | 0 | 0 |
| Diarrhea | 6 | 3 | 0 | 0 |
| Nausea | 8 | 1 | 2 | 0 |
| Oral mucositis | 0 | 1 | 1 | 0 |
| Vomiting | 6 | 0 | 1 | 0 |
| Cardiovascular | ||||
| Hypertension | 0 | 0 | 1 | 0 |
| Infection | ||||
| Lung | 0 | 0 | 1 | 0 |
| Tenosynovitis | 0 | 0 | 1 | 0 |
| Urinary tract | 0 | 1 | 0 | 0 |
| Endocrine and Chemistry | ||||
| Hypothyroidism | 0 | 1 | 0 | 0 |
| Nervous System | ||||
| Dizziness | 1 | 0 | 0 | 0 |
| Headache | 1 | 0 | 0 | 0 |
| Paresthesia | 1 | 0 | 0 | 0 |
| Syncope | 0 | 0 | 1 | 0 |
| Respiratory, Thoracic, and Mediastinal | ||||
| Dyspnea | 1 | 0 | 0 | 0 |
| Cough | 1 | 1 | 0 | 0 |
| Eye Disorders | ||||
| Blurred vision | 1 | 0 | 0 | 0 |
| Optic nerve disorder | 0 | 1 | 0 | 0 |
| Ear and Labyrinth Disorders | ||||
| Hearing impairment | 0 | 1 | 1 | 0 |
| Tinnitus | 1 | 0 | 0 | 0 |
| General | ||||
| Fatigue | 1 | 2 | 1 | 0 |
| Edema, limbs | 1 | 0 | 0 | 0 |
| Localized edema | 1 | 0 | 0 | 0 |
| Pain, extremity | 0 | 1 | 0 | 0 |
| Weight loss | 1 | 0 | 0 | 0 |
| Musculoskeletal and Connective Tissue | ||||
| Arthralgia | 2 | 0 | 0 | 0 |
| Arthritis | 0 | 1 | 0 | 0 |
| Myalgia | 2 | 0 | 0 | 0 |
| Musculoskeletal/connective tissue, leg cramps | 1 | 1 | 0 | 0 |
| Musculoskeletal/connective tissue, muscle cramps | 0 | 0 | 1 | 0 |
| Muscle weakness, lower limb | 0 | 0 | 1 | 0 |
| Skin, Subcutaneous Tissue | ||||
| Erythema | 1 | 0 | 0 | 0 |
| Pruritis | 1 | 0 | 0 | 0 |
| Rash, maculopapular | 2 | 0 | 0 | 0 |
| Metabolism and Nutrition | ||||
| Dehydration | 0 | 1 | 0 | 0 |