Adverse events (n = 17)

Adverse EventGrade 1Grade 2Grade 3Grade 4
Hematology
 Anemia3240
 Leukopenia4110
 Lymphopenia0211
 Neutropenia0010
 Thrombocytopenia3010
Gastrointestinal Disorders
 Abdominal pain1000
 Anorexia1100
 AST increased1000
 Bloating0100
 Dysgeusia0100
 Dyspepsia2000
 Diarrhea6300
 Nausea8120
 Oral mucositis0110
 Vomiting6010
Cardiovascular
 Hypertension0010
Infection
 Lung0010
 Tenosynovitis0010
 Urinary tract0100
Endocrine and Chemistry
 Hypothyroidism0100
Nervous System
 Dizziness1000
 Headache1000
 Paresthesia1000
 Syncope0010
Respiratory, Thoracic, and Mediastinal
 Dyspnea1000
 Cough1100
Eye Disorders
 Blurred vision1000
 Optic nerve disorder0100
Ear and Labyrinth Disorders
 Hearing impairment0110
 Tinnitus1000
General
 Fatigue1210
 Edema, limbs1000
 Localized edema1000
 Pain, extremity0100
 Weight loss1000
Musculoskeletal and Connective Tissue
 Arthralgia2000
 Arthritis0100
 Myalgia2000
 Musculoskeletal/connective tissue, leg cramps1100
 Musculoskeletal/connective tissue, muscle cramps0010
 Muscle weakness, lower limb0010
Skin, Subcutaneous Tissue
 Erythema1000
 Pruritis1000
 Rash, maculopapular2000
Metabolism and Nutrition
 Dehydration0100